An mRNA expression-based signature for oncogene-induced replication-stress

Link to paper Sergi Guerrero Llobet, Arkajyoti Bhattacharya, Marieke Everts, Klaas Kok, Bert van der Vegt, Rudolf S. N. Fehrmann & Marcel A. T. M. van Vugt Abstract Oncogene-induced replication stress characterizes many aggressive cancers. Several treatments are being developed that target replication stress, however, identification of tumors with high levels of replication stress remains…

mRNA-1273 COVID-19 vaccination in patients receiving chemotherapy, immunotherapy, or chemoimmunotherapy for solid tumours: a prospective, multicentre, non-inferiority trial

Link to paper Sjoukje F Oosting, Astrid A M van der Veldt, Corine H GeurtsvanKessel, Rudolf S N Fehrmann, Rob S van Binnendijk, Anne-Marie C Dingemans, Egbert F Smit, T Jeroen N Hiltermann, Gerco den Hartog, Mathilda Jalving, Tatjana T Westphal, Arkajyoti Bhattacharya, Marieke van der Heiden, Guus F Rimmelzwaan, Pia Kvistborg, Christian U Blank,…

Gallbladder Cancer: Current Insights in Genetic Alterations and Their Possible Therapeutic Implications

Link to paper Kuipers H, de Bitter TJJ, de Boer MT, van der Post RS, Nijkamp MW, de Reuver PR, Fehrmann RSN,Hoogwater FJH. Simple SummaryKnowledge of genetic alterations in gallbladder cancer (GBC) continues to increase. This systematic review provides an overview of frequently occurring genetic alterations in GBC and describes their possible therapeutic implications. We…

Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines

Link to paper Leeuwenburgh VC, Urzúa-Traslaviña CG, Bhattacharya A, Walvoort MTC, Jalving M, de Jong S, Fehrmann RSN. Abstract Background: Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern of all heterogeneous tumor and non-tumor cells present in…

Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy

Link to paper Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast. Abstract Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive…

Thesis defence Cyrillo Brahm

The 3th of June Cyrillo Brahm succesfully defended his thesis titled: “Improving the standard of care in glioblastoma: novel diagnostic and therapeutic approaches”. It was a privilege to supervise Cyrillo. I’m also very happy that he started his training for Internal Medicine, and the fact that he may become a colleague medical oncologist in the…

Sergi Guerrero successfully defended his PhD-thesis

Sergi Guerrero successfully defended his PhD-thesis today! Jointly supervised as co-promotor with Marcel van Vugt. https://www.rug.nl/about-ug/latest-news/events/promoties/?hfId=118982 https://research.rug.nl/nl/publications/exploiting-genomic-instability-as-an-achilles-heel-in-cancer Genomic instability is a hallmark of cancer for which an important cause is the DNA damage generated by oncogene-induced replication stress (RS). Genomically instable cancers increasingly depend on checkpoint kinases, including ATR and WEE1, to activate the DNA…

Improving gene function predictions using independent transcriptional components

Link to paper Urzúa-Traslaviña CG, Leeuwenburgh VC, Bhattacharya A, Loipfinger S, van Vugt MATM, de Vries EGE, Fehrmann RSN. ABSTRACT The interpretation of high throughput sequencing data is limited by our incomplete functional understanding of coding and non-coding transcripts. Reliably predicting the function of such transcripts can overcome this limitation. Here we report the use…