The antibody-drug conjugate target landscape across a broad range of tumour types

The antibody-drug conjugate target landscape across a broad range of tumour types Annals of Oncology, mdx541, https://doi.org/10.1093/annonc/mdx541 K.L. Moek D.J.A. de Groot E.G.E. de Vries R.S.N. Fehrmann Background Antibody-drug conjugates (ADCs), consisting of an antibody designed against a specific target at the cell membrane linked with a cytotoxic agent, are an emerging class of therapeutics.…

Theranostics Using Antibodies and Antibody-Related Therapeutics

Theranostics Using Antibodies and Antibody-Related Therapeutics. J Nucl Med. 2017 Sep;58(Suppl 2):83S-90S. doi: 10.2967/jnumed.116.186940. Kirsten L. Moek, Danique Giesen, Iris C. Kok, Derk Jan A. de Groot, Mathilde Jalving, Rudolf S.N. Fehrmann, Marjolijn N. Lub-de Hooge, Adrienne H. Brouwers and Elisabeth G.E. de Vries In theranostics, radiolabeled compounds are used to determine a treatment strategy…

Carlos Urzua joins the group

Carlos is a medical doctor from Mexico with good bioinformatical skills. So I’m very happy that Carlos with his rare combination of skills is joining our group. Carlos previously was a topmaster student in the Medical Pharmaceutical Drug Innovation (MPDI) topmaster at the University of Groningen / University Medical Center Groningen and worked in my…

Vincent Leeuwenburgh will join the group in 2017

I’m happy to announce that Vincent Leeuwenburgh will join my group in 2017. Vincent applied in May 2017 for one of the Young Academy Interdisciplinary PhD positions and was selected based on an excellent research proposal written by him. I will jointly supervise this project with Marthe Walvoort (assistant professor at the Faculty of Science…

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. Theranostics 2017; 7(2):482-492. doi:10.7150/thno.16816 Elmire Hartmans, Veronique Orian-Rousseau, Alexandra Matzke-Ogi, Arend Karrenbeld, Derk Jan A. de Groot, Steven de Jong, Gooitzen M. van Dam, Rudolf S.N. Fehrmann*, Wouter B. Nagengast* * Contributed equally…

POINTING project will be funded by the KWF!

I’m very happy to announce that we have received good news from the Dutch Cancer Society. The project: ‘POINTING: Towards patient-tailored cancer immunotherapy supported by a multifaceted predictive signature composed of integrative omics and molecular imaging’ will receive funding from the ‘PROGRAMME RESEARCH & IMPLEMENTATION CALL 2016-I’. As one of the four principal investigators on…

New master student Carlos G. Urzua Traslavina

As of first of November, Carlos G. Urzua Traslavina joined the group for a 6 month project. Carlos is a topmaster student in the Medical Pharmaceutical Drug Innovation (MPDI) topmaster. He will be working on the subject: Classifying primary unknowns with gene expression profiles and neural networks. Very happy with that a MD is excited…

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer paper is now accessible online at the Journal of the National Cancer Institute. JNCI J Natl Cancer Inst (2017) 109 (1): djw192 doi: 10.1093/jnci/djw192 Rico D. Bense, Christos Sotiriou, Martine J. Piccart-Gebhart, John B. A. G. Haanen, Marcel A. T. M.…

Arkajyoti Bhattacharya started within my group

Arkajyoti Bhattacharya is starting as a PhD-student in my group. He is a trained statistician from the Indian Statistical Institute and will be working on the project ‘Mining big data to improve biologically personalized therapeutics for cancer patients’.