Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE

Very proud that the Dutch Cancer Society is willing to fund the FORCE initiative grant: Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE. FORCE aims to improve treatment outcomes of rare cancers by collecting clinical data on patients with rare cancers and by…

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Link to paper Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel & Marcel A. T. M. van Vugt. AbstractOncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high…

Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy

Link to paper Lars C. Steggink, Hink Boer, Coby Meijer, Joop D. Lefrandt, Leon W. M. M. Terstappen, Rudolf S. N. Fehrmann & Jourik A. Gietema. AbstractGenetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ…

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Link to paper Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock & Marcel A. T. M. van Vugt. Abstract Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells,…

Artificial intelligence is not going to replace the doctor in the near future

I’ve been interviewed for the monthly journal of the Dutch Society Of Medical Oncology on the subject of Artificial Intelligence in oncology/healtcare. The interview is in Dutch (but google translate does a good job of translating it to English, or try DeepL Translate). De term kunstmatige intelligentie, meestal artificial intelligence genoemd, zoemt in toenemende mate…

Immune microenvironment composition in non‐small cell lung cancer and its association with survival

Link to paper Tamminga M, Hilterman TJN, Schuuring E, Timens W, Fehrmann RSN, Groen HJM. Abstract Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. In this in silico study, the immune infiltrate composition in NSCLC patients was evaluated. Methods Gene expression data of tumors from early NSCLC patients were…

Comparison of Carboplatin With 5-Fluorouracil vs. Cisplatin as Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

link to paper Hanemaaijer S, Kok I, Fehrmann RSN, van der Vegt B, Gietema J, Plaat B, van Vugt MATM, Vergeer M, Leemans RC, Langendijk JA, Voortman J, Buter J, Oosting JF. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma…