Link to paper Astrid A. M. van der Veldt, Sjoukje F. Oosting, Anne-Marie C. Dingemans, Rudolf S. N. Fehrmann, Corine Geurts van Kessel, Mathilde Jalving, Guus F. Rimmelzwaan, Pia Kvistborg, Christian U. Blank, Egbert F. Smit, Valery E. E. P. Lemmens, T. Jeroen N. Hiltermann, Marion P. G. Koopmans, Anke L. W. Huckriede, Nynke Y.…
Link to paper van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K. BackgroundAnastomotic leakage in patients undergoing colorectal surgery is associated with morbidity and mortality. Although multiple risk factors have been identified, the underlying mechanisms are mainly unknown. The aim of this study was to perform a transcriptome…
Link to paper Cyrillo G Brahm, U Kulsoom Abdul, Megan Houweling, Myra E van Linde, Tonny Lagerweij, Henk M W Verheul, Bart A Westerman, Annemiek M E Walenkamp, Rudolf S N Fehrmann. BackgroundPatients with glioblastoma (GBM) have a dismal prognosis, and there is an unmet need for new therapeutic options. This study aims to identify…
Link to paper Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel & Marcel A. T. M. van Vugt. AbstractOncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high…
Link to paper Lars C. Steggink, Hink Boer, Coby Meijer, Joop D. Lefrandt, Leon W. M. M. Terstappen, Rudolf S. N. Fehrmann & Jourik A. Gietema. AbstractGenetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ…
Link to paper Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock & Marcel A. T. M. van Vugt. Abstract Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells,…
I’ve been interviewed for the monthly journal of the Dutch Society Of Medical Oncology on the subject of Artificial Intelligence in oncology/healtcare. The interview is in Dutch (but google translate does a good job of translating it to English, or try DeepL Translate). De term kunstmatige intelligentie, meestal artificial intelligence genoemd, zoemt in toenemende mate…
Interview with me on Artificial Intelligence in Health Care (Oncology). Will appear also online in the near future at https://medischeoncologie.nl/.
Link to paper Tamminga M, Hilterman TJN, Schuuring E, Timens W, Fehrmann RSN, Groen HJM. Abstract Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. In this in silico study, the immune infiltrate composition in NSCLC patients was evaluated. Methods Gene expression data of tumors from early NSCLC patients were…
link to paper Hanemaaijer S, Kok I, Fehrmann RSN, van der Vegt B, Gietema J, Plaat B, van Vugt MATM, Vergeer M, Leemans RC, Langendijk JA, Voortman J, Buter J, Oosting JF. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma…