Transcriptional effects of copy number alterations in a large set of human cancers

Link to paper Bhattacharya A, Bense RD, Urzúa-Traslaviña CG, de Vries EGE, van Vugt MATM, Fehrmann RSN AbstractCopy number alterations (CNAs) can promote tumor progression by altering gene expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not always translate proportionally into altered expression levels. By reanalyzing >34,000 gene expression profiles, we reveal the…

Driving innovation for rare skin cancers: utilising common tumours and machine learning to predict immune checkpoint inhibitor response

Link to paper J.S. Hooiveld-Noeken, R.S.N. Fehrmann, E.G.E. de Vries, M. Jalving Highlights • Metastatic Merkel- and cutaneous squamous cell carcinoma are rare tumours. • Immunotherapy gives impressive responses but most patients do not survive long-term. • Small patients numbers prevent extensive biomarker research in clinical trials. • Pooled data from common and rare tumours…

Rico Bense successfully defended his PhD thesis

On Wednesday November 20th, Rico Bense successfully defended his PhD thesis. See the summary description of his thesis below: In clinical practice, breast cancer is currently divided into subtypes based on immunohistochemical expression of the estrogen receptor and human epidermal growth factor receptor 2. These subtypes are crucial for treatment choice and outcome. However, even…

Research proposal selected for funding by Hanarth Fonds

Last Friday I received an email with some great news 🙂 The Scientific Advisory Board and the Board of the Hanarth Fonds have decided that 6 candidates are eligible for funding of their proposal. The quality of the proposals was very good and we are happy to inform you that your proposal has been selected…

What is the future role of artificial intelligence in medical oncology?

The Medical Oncologist perspective With great pleasure I chaired the session “What s the future role of artificial intelligence in medical oncology?” at the European Society for Medical Oncology (ESMO) congress 2019. Also good to see so many people attending this session. For those that are interested in the presentation, I provide the presentation here.…

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers

Link to paper Peters MAM, Meijer C, Fehrmann RSN, Walenkamp AME, Kema IP, de Vries EGE, Hollema H, Oosting SF. Abstract In preclinical studies serotonin stimulates and dopamine inhibits tumour growth and angiogenesis. Information regarding serotonin and dopamine receptor (5-HTR and DRD) expression in human cancers is limited. Therefore, we screened a large tumour set…