The 3th of June Cyrillo Brahm succesfully defended his thesis titled: “Improving the standard of care in glioblastoma: novel diagnostic and therapeutic approaches”. It was a privilege to supervise Cyrillo. I’m also very happy that he started his training for Internal Medicine, and the fact that he may become a colleague medical oncologist in the…
Sergi Guerrero successfully defended his PhD-thesis today! Jointly supervised as co-promotor with Marcel van Vugt. https://www.rug.nl/about-ug/latest-news/events/promoties/?hfId=118982 https://research.rug.nl/nl/publications/exploiting-genomic-instability-as-an-achilles-heel-in-cancer Genomic instability is a hallmark of cancer for which an important cause is the DNA damage generated by oncogene-induced replication stress (RS). Genomically instable cancers increasingly depend on checkpoint kinases, including ATR and WEE1, to activate the DNA…
Link to paper Urzúa-Traslaviña CG, Leeuwenburgh VC, Bhattacharya A, Loipfinger S, van Vugt MATM, de Vries EGE, Fehrmann RSN. ABSTRACT The interpretation of high throughput sequencing data is limited by our incomplete functional understanding of coding and non-coding transcripts. Reliably predicting the function of such transcripts can overcome this limitation. Here we report the use…
Link to paper Astrid A. M. van der Veldt, Sjoukje F. Oosting, Anne-Marie C. Dingemans, Rudolf S. N. Fehrmann, Corine Geurts van Kessel, Mathilde Jalving, Guus F. Rimmelzwaan, Pia Kvistborg, Christian U. Blank, Egbert F. Smit, Valery E. E. P. Lemmens, T. Jeroen N. Hiltermann, Marion P. G. Koopmans, Anke L. W. Huckriede, Nynke Y.…
Link to paper van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K. BackgroundAnastomotic leakage in patients undergoing colorectal surgery is associated with morbidity and mortality. Although multiple risk factors have been identified, the underlying mechanisms are mainly unknown. The aim of this study was to perform a transcriptome…
Very proud that the Dutch Cancer Society is willing to fund the FORCE initiative grant: Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE. FORCE aims to improve treatment outcomes of rare cancers by collecting clinical data on patients with rare cancers and by…
Link to paper Cyrillo G Brahm, U Kulsoom Abdul, Megan Houweling, Myra E van Linde, Tonny Lagerweij, Henk M W Verheul, Bart A Westerman, Annemiek M E Walenkamp, Rudolf S N Fehrmann. BackgroundPatients with glioblastoma (GBM) have a dismal prognosis, and there is an unmet need for new therapeutic options. This study aims to identify…
Link to paper Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel & Marcel A. T. M. van Vugt. AbstractOncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high…
Link to paper Lars C. Steggink, Hink Boer, Coby Meijer, Joop D. Lefrandt, Leon W. M. M. Terstappen, Rudolf S. N. Fehrmann & Jourik A. Gietema. AbstractGenetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ…
Link to paper Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock & Marcel A. T. M. van Vugt. Abstract Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells,…