Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy

Link to paper Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast. Abstract Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive…

Thesis defence Cyrillo Brahm

The 3th of June Cyrillo Brahm succesfully defended his thesis titled: “Improving the standard of care in glioblastoma: novel diagnostic and therapeutic approaches”. It was a privilege to supervise Cyrillo. I’m also very happy that he started his training for Internal Medicine, and the fact that he may become a colleague medical oncologist in the…

Sergi Guerrero successfully defended his PhD-thesis

Sergi Guerrero successfully defended his PhD-thesis today! Jointly supervised as co-promotor with Marcel van Vugt. https://www.rug.nl/about-ug/latest-news/events/promoties/?hfId=118982 https://research.rug.nl/nl/publications/exploiting-genomic-instability-as-an-achilles-heel-in-cancer Genomic instability is a hallmark of cancer for which an important cause is the DNA damage generated by oncogene-induced replication stress (RS). Genomically instable cancers increasingly depend on checkpoint kinases, including ATR and WEE1, to activate the DNA…

Improving gene function predictions using independent transcriptional components

Link to paper Urzúa-Traslaviña CG, Leeuwenburgh VC, Bhattacharya A, Loipfinger S, van Vugt MATM, de Vries EGE, Fehrmann RSN. ABSTRACT The interpretation of high throughput sequencing data is limited by our incomplete functional understanding of coding and non-coding transcripts. Reliably predicting the function of such transcripts can overcome this limitation. Here we report the use…

Colorectal anastomotic leak: transcriptomic profile analysis

Link to paper van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K. BackgroundAnastomotic leakage in patients undergoing colorectal surgery is associated with morbidity and mortality. Although multiple risk factors have been identified, the underlying mechanisms are mainly unknown. The aim of this study was to perform a transcriptome…

Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE

Very proud that the Dutch Cancer Society is willing to fund the FORCE initiative grant: Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE. FORCE aims to improve treatment outcomes of rare cancers by collecting clinical data on patients with rare cancers and by…

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Link to paper Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel & Marcel A. T. M. van Vugt. AbstractOncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high…