Indispensable benefit of independent investigator-driven research in a changing clinical trial landscape

Indispensable benefit of independent investigator-driven research in a changing clinical trial landscape. ESMO Open; DOI: 10.1136/esmoopen-2017-000272 Sjoukje F Oosting, Rudolf S Fehrmann, Elisabeth G E de Vries In the Oxford dictionary, ‘Independent’ is defined as ‘Free from outside control; not subject to another’s authority’. Independence can be critical to identify important issues for patients. The…

The antibody-drug conjugate target landscape across a broad range of tumour types

The antibody-drug conjugate target landscape across a broad range of tumour types Annals of Oncology, mdx541, https://doi.org/10.1093/annonc/mdx541 K.L. Moek D.J.A. de Groot E.G.E. de Vries R.S.N. Fehrmann Background Antibody-drug conjugates (ADCs), consisting of an antibody designed against a specific target at the cell membrane linked with a cytotoxic agent, are an emerging class of therapeutics.…

Theranostics Using Antibodies and Antibody-Related Therapeutics

Theranostics Using Antibodies and Antibody-Related Therapeutics. J Nucl Med. 2017 Sep;58(Suppl 2):83S-90S. doi: 10.2967/jnumed.116.186940. Kirsten L. Moek, Danique Giesen, Iris C. Kok, Derk Jan A. de Groot, Mathilde Jalving, Rudolf S.N. Fehrmann, Marjolijn N. Lub-de Hooge, Adrienne H. Brouwers and Elisabeth G.E. de Vries In theranostics, radiolabeled compounds are used to determine a treatment strategy…

Carlos Urzua joins the group

Carlos is a medical doctor from Mexico with good bioinformatical skills. So I’m very happy that Carlos with his rare combination of skills is joining our group. Carlos previously was a topmaster student in the Medical Pharmaceutical Drug Innovation (MPDI) topmaster at the University of Groningen / University Medical Center Groningen and worked in my…

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. Theranostics 2017; 7(2):482-492. doi:10.7150/thno.16816 Elmire Hartmans, Veronique Orian-Rousseau, Alexandra Matzke-Ogi, Arend Karrenbeld, Derk Jan A. de Groot, Steven de Jong, Gooitzen M. van Dam, Rudolf S.N. Fehrmann*, Wouter B. Nagengast* * Contributed equally…

POINTING project will be funded by the KWF!

I’m very happy to announce that we have received good news from the Dutch Cancer Society. The project: ‘POINTING: Towards patient-tailored cancer immunotherapy supported by a multifaceted predictive signature composed of integrative omics and molecular imaging’ will receive funding from the ‘PROGRAMME RESEARCH & IMPLEMENTATION CALL 2016-I’. As one of the four principal investigators on…

New master student Carlos G. Urzua Traslavina

As of first of November, Carlos G. Urzua Traslavina joined the group for a 6 month project. Carlos is a topmaster student in the Medical Pharmaceutical Drug Innovation (MPDI) topmaster. He will be working on the subject: Classifying primary unknowns with gene expression profiles and neural networks. Very happy with that a MD is excited…

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer paper is now accessible online at the Journal of the National Cancer Institute. JNCI J Natl Cancer Inst (2017) 109 (1): djw192 doi: 10.1093/jnci/djw192 Rico D. Bense, Christos Sotiriou, Martine J. Piccart-Gebhart, John B. A. G. Haanen, Marcel A. T. M.…