Link to paper Tamminga M, Hilterman TJN, Schuuring E, Timens W, Fehrmann RSN, Groen HJM. Abstract Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. In this in silico study, the immune infiltrate composition in NSCLC patients was evaluated. Methods Gene expression data of tumors from early NSCLC patients were…
Presented at the ESMO BREAST CANCER VIRTUAL MEETING 2020. You can download the presentation (with audio) HERE.
link to paper Hanemaaijer S, Kok I, Fehrmann RSN, van der Vegt B, Gietema J, Plaat B, van Vugt MATM, Vergeer M, Leemans RC, Langendijk JA, Voortman J, Buter J, Oosting JF. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma…
Link to paper Workel HH, van Rooij N, Plat A, Spierings DCJ, Fehrmann RSN, Nijman HW. de Bruyn M Abstract: Tumor-infiltrating CD8+ T cells (TIL) are of the utmost importance in anti-tumor immunity. CD103 defines tumor-resident memory T cells (TRM cells) associated with improved survival and response to immune checkpoint blockade (ICB) across human tumors. Co-expression…
Link to paper Knapen DJ, Kwee TC, Meijne EIM, Fehrmann RSN, de Vries EGE AbstractImmune checkpoint inhibitors (ICI) have improved outcomes for patients with advanced cancers, and results in increasing numbers of long-term survivors. For registration studies, progression-free survival and disease-free survival often serve as primary endpoints. This requires repeated computed tomography (CT) scans for…
Link to paper Boonstra PA, Wind TT, van Kruchten M, Schuuring E, Hospers GAP, van der Wekken AJ, de Groot DJ, Schröder CP, Fehrmann RSN, Reyners AKL AbstractResponse evaluation for cancer treatment consists primarily of clinical and radiological assessments. In addition, a limited number of serum biomarkers that assess treatment response are available for a…
On Monday February 24th, Kirsten Moek successfully defended his PhD thesis. See the summary description of his thesis below: Over the last decades many molecules and key pathways in cancer were identified, which facilitated a shift in anticancer drug development from DNA-damaging chemotherapy to a more personalized approach with targeted antibody therapeutics including antibody-drug conjugates (ADC)…
Link to paper Bhattacharya A, Bense RD, Urzúa-Traslaviña CG, de Vries EGE, van Vugt MATM, Fehrmann RSN AbstractCopy number alterations (CNAs) can promote tumor progression by altering gene expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not always translate proportionally into altered expression levels. By reanalyzing >34,000 gene expression profiles, we reveal the…
Link to paper van de Donk PP, Kist de Ruijter L, Lub-de Hooge MN, Brouwers AH, van der Wekken AJ, Oosting SF, Fehrmann RSN, de Groot DJA, de Vries EGE Immune checkpoint inhibitors (ICIs) have substantially changed the field of oncology over the past few years. ICIs offer an alternative treatment strategy by exploiting the…
Working environment “Using machine learning to unravel the ‘cancer-immune setpoint’ in cancers.” We have an exciting opportunity for a PhD student. The position will be for 4 years and should results in a PhD thesis at the University of Groningen. The PhD student position is available in the research group of dr. Rudolf Fehrmann. The…