Link to paper Urzúa-Traslaviña CG, Leeuwenburgh VC, Bhattacharya A, Loipfinger S, van Vugt MATM, de Vries EGE, Fehrmann RSN. ABSTRACT The interpretation of high throughput sequencing data is limited by our incomplete functional understanding of coding and non-coding transcripts. Reliably predicting the function of such transcripts can overcome this limitation. Here we report the use…
Link to paper Astrid A. M. van der Veldt, Sjoukje F. Oosting, Anne-Marie C. Dingemans, Rudolf S. N. Fehrmann, Corine Geurts van Kessel, Mathilde Jalving, Guus F. Rimmelzwaan, Pia Kvistborg, Christian U. Blank, Egbert F. Smit, Valery E. E. P. Lemmens, T. Jeroen N. Hiltermann, Marion P. G. Koopmans, Anke L. W. Huckriede, Nynke Y.…
Link to paper van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K. BackgroundAnastomotic leakage in patients undergoing colorectal surgery is associated with morbidity and mortality. Although multiple risk factors have been identified, the underlying mechanisms are mainly unknown. The aim of this study was to perform a transcriptome…
Very proud that the Dutch Cancer Society is willing to fund the FORCE initiative grant: Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE. FORCE aims to improve treatment outcomes of rare cancers by collecting clinical data on patients with rare cancers and by…
Link to paper Cyrillo G Brahm, U Kulsoom Abdul, Megan Houweling, Myra E van Linde, Tonny Lagerweij, Henk M W Verheul, Bart A Westerman, Annemiek M E Walenkamp, Rudolf S N Fehrmann. BackgroundPatients with glioblastoma (GBM) have a dismal prognosis, and there is an unmet need for new therapeutic options. This study aims to identify…
Link to paper Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel & Marcel A. T. M. van Vugt. AbstractOncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high…
Link to paper Lars C. Steggink, Hink Boer, Coby Meijer, Joop D. Lefrandt, Leon W. M. M. Terstappen, Rudolf S. N. Fehrmann & Jourik A. Gietema. AbstractGenetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ…
Link to paper Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock & Marcel A. T. M. van Vugt. Abstract Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells,…
I’ve been interviewed for the monthly journal of the Dutch Society Of Medical Oncology on the subject of Artificial Intelligence in oncology/healtcare. The interview is in Dutch (but google translate does a good job of translating it to English, or try DeepL Translate). De term kunstmatige intelligentie, meestal artificial intelligence genoemd, zoemt in toenemende mate…
Interview with me on Artificial Intelligence in Health Care (Oncology). Will appear also online in the near future at https://medischeoncologie.nl/.