Abstracts

2023

Carolina R.C. Pieterman, Nathalie van den Tempel, Marcus W Dercksen, Koen MA Dreijerink, Rudolf Stephan Nicolaas Fehrmann, Wouter W. de Herder, Johannes Hofland, Mathilde Jalving, Heinz-Josef Klümpen, Loes M Latten-Jansen, Luc Linden, Els JM Nieveen van Dijkum, Michiel B de Ruiter, Ed Schuuring, Marga Schrieks, Morris A Swertz, Margot ET Tesselaar, Dirk J Veldman, Gerlof D Valk, Anna Maria Elisabeth Walenkamp. Infrastructure for rare cancer in the Netherlands: Towards a comprehensive platform for early detection and diagnosis of rare cancers (FORCE). Journal of Clinical Oncology 41, no. 16_suppl (June 01, 2023) TPS1612-TPS1612 .

2022

Jeroen E. van Schaik, Bert van der Vegt, Bernard F.A.M. van der Laan, Max J.H. Witjes, Sjoukje F. Oosting, Rudolf S. Fehrmann, Boudewijn E. Plaat. Identification of molecular imaging targets specific for head and neck squamous cell carcinoma by transcriptional adaptation to copy number alterations profiling: Digital data translated to protein expression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6260.

Jeroen E. van Schaik, Bert van der Vegt, Saskia H. Hanemaaijer, Gyorgy B. Halmos, Max J. Witjes, Bernard F.A.M. van der Laan, Rudolf S. Fehrmann, Sjoukje F. Oosting, Boudewijn E. Plaat. Comparison of glycoprotein nonmetastatic melanoma protein b, epidermal growth factor receptor and vascular endothelial growth factor expression in head and neck squamous cell carcinoma, and untreated and residual lymph node metastases [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6261.

Arkajyoti Bhattacharya, Carlos G. Urzúa-Traslaviña, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann. Eliminating copy number alteration effects in the gene essentiality data from the Cancer Dependency Map project [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5019.

Pascal Jonker, Madelon Metman, Luc Sondorp, Mark Sywak, Anthony Gill, Liesbeth Jansen, Thera Links, Paul van Diest, Tessa van Ginhoven, Clemens Löwik, Ahn Nguyen, Rob Coppes, Dominic Robinson, Gooitzen van Dam, Bettien van Hemel, Rudolf Fehrmann, Schelto Kruijff. MET Targeted Molecular Fluorescence Guided Imaging and Quantitative Spectroscopy for the Detection of Lymph Node Metastases in Papillary Thyroid Cancer. European Journal of Surgical Oncology; 2022: 48:e49-e50.

2021

Sjoukje Oosting, AAM Van der Veldt, CH GeurtsvanKessel, RSN Fehrmann, RS Van Binnendijk, AM C Dingemans, EFF Smit, TJN Hiltermann, G Den Hartog, M Jalving, T Westphal, A Battacharya, M van der Heiden, CU Blank, MP Koopmans, CA van Els, NY Rots, D van Baarle, JBAG Haanen, EG de Vries. LBA8 Vaccination against SARS-CoV-2 in patients receiving chemotherapy, immunotherapy, or chemo-immunotherapy for solid tumors. Annals of Oncology; 2021: 32:S1337.

2020

Gabriela GF Giovanna Femma van der Schoot, Harm Laurens Ormel, Nico-Derk L Westerink, Annette Van Der Velden, Boelo Jan Poppema, Rudolf Stephan Nicolaas Fehrmann, Joop D Lefrandt, Arie M van Roon, Joost van Melle, Peter Van der Meer, Johan B Wempe, Marcel ten Wolde, Joyce Stel, Aline H Vrieling, Niek de Boer, Anne Maria May, Sjoerd G Elias, Jourik A Gietema, Anna Maria Elisabeth Walenkamp. Effect of a tailored exercise intervention during or after chemotherapy on cardiovascular morbidity in cancer patients. J Clin Oncol 38, 2020, 12018-12018.

Anne M. Hendriks, Christos E. Zois, Syed B. Haider, Elisabete Pires, Dimitra Kalamida, Christoffer Lagerholm, John Morris, James S. McCullagh, Rudolf S. Fehrmann, Wilfred F. den Dunnen, Adrian L. Harris, Mathilde Jalving. Inhibition of glycogen degradation sensitizes glioblastoma cells to ionizing radiation [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 240.

Madelon Metman, Luc Sondorp, Pascal Jonker, Mark Sywak, Anthony Gill, Bettien van Hemel, Liesbeth Jansen, Paul van Diest, Gooitzen van Dam, Rob Coppes, Rudolf Fehrmann, Schelto Kruijff. Detection of Papillary Thyroid Cancer Nodal Metastasis after Intravenous Administration of a Fluorescent Tracer Targeting MET. European Journal of Surgical Oncology 46 (2), e21.

2019

P.K.C. Jonker, M.J.H. Metman, L.H.J. Sondorp, M.S. Sywak, A.J. Gill, B.M. van Hemel, L. Jansen, P.J. van Diest, G.M. van Dam, R.P. Coppes, R.S.N. Fehrmann, S. Kruijff. Title: De MET specifieke fluorescente tracer EMI-137 is geschikt voor de in vivo detectie van papillair schildkliercarcinoom lymfkliermetastasen. SEOHS 2019. Amsterdam, The Netherlands. December 6th, 2019.

L.H.J. Sondorp, P.K.C. Jonker, M.S. Sywak, G.M. van Dam, A.J. Gill, P.J. van Diest,R.S.N. Fehrmann, S. Kruijff. Title: MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Oral presentation, presented by Luc Sondorp. 39th Congress of the European Society of Surgical Oncology. Rotterdam, the Netherlands. October 9-11, 2019.

P.K.C. Jonker, L.H.J. Sondorp, M.S. Sywak, G.M. van Dam, A.J. Gill, P.J. van Diest,R.S.N. Fehrmann, S. Kruijff. MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Poster Presentation. Biannual meeting International Association of Endocrine Surgeons, Krakow, August 11-15, 2019.

J.B. van Praagh, P. Olinga, J.J.de Haan, W.B. Nagengast, R.S.N Fehrmann, K. Havenga. Transcriptomic profiles of patients’ peroperative samples developing colorectal anastomotic leak show distinct signature. 39th Annual Meeting of the Surgical Infection Society in San Diego, CA, June 5-8, 2019

2018

V. Leeuwenburgh, A. Bhattacharya, C. Urzua, M. Walvoort, H. Jalving, S. de Jong, R. Fehrmann. The metabolic landscape browser: a novel tool for understanding pan-cancer metabolic processes through variance in gene expression data, 2018, vol. 103, p. E106-E106. European journal of cancer

T. Stutvoet, A. Kol, E. de Vries, M. de Bruyn, R. Fehrmann, A. Terwisscha van Scheltinga, S. de Jong. MAPK pathway activity plays a key role in programmed death ligand-1 expression of EGFR wild-type non-small cell lung adenocarcinoma cells, 2018, vol. 103, p. E78-E79. European journal of cancer

Van Meerten, T., Bouwstra, R., He, Y., Janneke, D. B., Kooistra, H., Fehrmann, R., Ammatuna, E., Huls, G., & Bremer, E. (2018). CD47 Expression Defines the Efficacy of Rituximab in Non-Germinal Center B-Cell (non-GCB) Diffuse Large B-Cell Lymphoma (DLBCL). Blood, 132, 2852. Accessed December 03, 2018. https://doi.org/10.1182/blood-2018-99-114561.

KL Moek, SJH Waaijer, IC Kok, FV Suurs, A Brouwers, CW Menke-van der Houven van Oordt, TT Wind, JA Gietema, CP Schroder, SVK Mahesh, A Jorritsma-Smit, MN Lub-De Hooge, RSN Fehrmann, DJ de Groot, EGE de Vries. Zirconium-89 (89Zr)-labeled bispecific T-cell engager (BiTE®) AMG 211 PET imaging to determine AMG 211 biodistribution in patients with gastrointestinal (GI) adenocarcinomas. Annals of Oncology, Volume 29, Issue suppl_8, 1 September 2018, mdy279.413.

Cyrillo G. Brahm, Annemiek M.E. Walenkamp, Myra E. van Linde, U. Kulsoom Abdul, Bart A. Westerman, Henk M.W. Verheul, Rudolf S.N. Fehrmann. Data-driven prioritization and evaluation of novel therapeutic targets in glioblastoma. 13th Meeting of the European Association of Neuro-Oncology (EANO 2018): 2018 Oct 10-14.

P.K.C. Jonker, M.S. Sywak, G.M. van Dam, A.J. Gill, P.J. van Diest,R.S.N. Fehrmann, S. Kruijff. MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Poster Presentation. 13th European Molecular Imaging Meeting, Bilbao, Spain. March 20-23, 2018.

P.K.C. Jonker, M.S. Sywak, G.M. van Dam, A.J. Gill, P.J. van Diest,R.S.N. Fehrmann, S. Kruijff. MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Poster Presentation. European Society of Endocrine Surgery Meeting, Amsterdam, the Netherlands. May 24-26, 2018.

P.K.C. Jonker, M.S. Sywak, D. Leeuw, G.M. van Dam, A.J. Gill, P.J. van Diest, S.F. Oosting, R.S.N. Fehrmann, S. Kruijff. MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Poster Presentation, last minute retraction because of poster confiscation on airport. 39th Annual Meeting of the American Association of Endocrine Surgeons, Durham, North Carolina, United States. May 6-8, 2018.

2017

P.K.C. Jonker, M.S. Sywak, G.M. van Dam, A.J. Gill, P.J. van Diest, R.S.N. Fehrmann, S. Kruijff. MET as Potential Target for Molecular Fluorescence Guided Surgery in Papillary Thyroid Carcinoma. Poster presentation, presented by G.M. van Dam. World Molecular Imaging Congress, Philidelphia, Pennsylvania, United States. September 13-16, 2017.

S.H. Hanemaaijer, I.C. Kok, R.S.N. Fehrmann, B. van der Vegt, J.A. Gietema, B.E.C. Plaat, M.A.T.M. Vugt, M.R. Vergeer, J. Voortman, C.R. Leemans, J. Buter, J.A. Langendijk, S.F. Oosting. Comparison of carboplatin with 5-fluorouracil (carbo-5FU) versus cisplatin as concomitant chemoradiotherapy (CRT) for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx374.026.

K.L. Moek, D.J. de Groot, E.G.E. de Vries, R.S.N. Fehrmann. Functional genomic mRNA (FGmRNA) profiling of > 18,000 tumor samples identifies potential new indications for antibody-drug conjugates (ADCs) in a broad range of tumor types. Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx390.070.

R.D. Bense, E.G.E. de Vries, C.P. Schröder, R.S.N. Fehrmann. Higher expression of estrogen response genes in the primary tumor is associated with a greater risk for late recurrence in patients with ER+/HER2-breast cancer. Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx362.046.

Cyrillo Gerardo Brahm, Anna Maria Elisabeth Walenkamp, Myra Ellen Van Linde, Henk M.W. Verheul, Rudolf Stephan Nicolaas Fehrmann. Identification of novel therapeutic targets in glioblastoma with functional genomic mRNA profiling. J Clin Oncol 35, 2017 (suppl; abstr 2018).

J.J. Caumanns, G.B.A Wisman, K. Berns, T. Tomar, R.S.N. Fehrmann, R. Bernards, A.G.J. Van der Zee, S. De Jong. Integrative kinome exome sequencing and copy number profiling of ovarian clear cell carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1219 / 4.

Menno Tamminga, T. Jeroen N. Hiltermann, Ed Schuuring, Rudolf S. N. Fehrmann, Harry J. M. Groen. Effect of smoking on tumor-infiltrating immune cell composition and prognosis in non-small cell lung cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 4569 / 14.

Menno Tamminga, T. Jeroen Hiltermann, Ed Schuuring, Rudolf S. N. Fehrmann, Harry J. M. Groen. Prognostic effect of tumor-infiltrating immune cell composition in non-small cell lung cancer by histology. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 2946 / 17.

Stephanie E. van Gijn, Elles Wierenga, Anne Margriet Heijink, Rudolf S. N. Fehrmann, Marcel A. van Vugt. Analysis of 16,172 patient-derived tumor samples indicate TPX2 as being essential for survival of genomically instable cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1409 / 8.

Sergi Guerrero, Rudolf Fehrmann, Marcel ATM van Vugt. Towards an RNA expression-based signature for oncogene-induced replication stress. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1406 / 5.

2016

P.K.C. Jonker, G.M. van Dam, S.F. Oosting, R.S.N. Fehrmann, S. Kruijff. Title: Identificatie van nieuwe therapeutische targets in anaplastisch schildkliercarcinoom met Functional Genomic mRNA-Profiling. Oral presentation (Dutch). Annual meeting of the Dutch Surgical Society. Veldhoven, the Netherlands. May 19-20, 2016.

Pascal K. C. Jonker, Gooitzen M. van Dam, MD, Sjoukje F. Oosting, Schelto Kruijff and Rudolf S. N. Fehrmann. The identification of novel biomarkers for diagnostic and therapeutic goals in Anaplastic Thyroid Carcinoma using Functional Genomic mRNA Profiling. American Association of Endocrine Surgeons (AAES) Annual Meeting 2016 April 10-12; Baltimore (MD), USA.

E Hartmans, V Orian-Rousseau, A Matzke-Ogi, A Karrenbeld, D J A de Groot, S de Jong, G M van Dam, R S N Fehrmann, W B Nagengast. CD44 and its splice variant CD44v6 as Potential Imaging and Treatment Targets for Colorectal Adenomas. 6th Dutch Experimental Gastroenterology and Hepatology (DEGH) meeting: 2016 Mar 16-18; Veldhoven, The Netherlands.

Bense RD, van der Vegt B, de Vries EGE, van Vugt MATM, Schröder CP, Fehrmann RSN. Inverse relationships between high somatic copy number load and immune phenotypes in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-08-01.

2015

P.K.C. Jonker, G.M. van Dam, S.F. Oosting, R.S.N. Fehrmann, S. Kruijff. Title: Identificatie van nieuwe therapeutische targets in anaplastisch schildkliercarcinoom met Functional Genomic mRNA-Profiling. Poster Presentation (Dutch). 28e Symposium Experimenteel Onderzoek Heelkundige Specialismen, Leiden, the Netherlands. December 11, 2015.

Harmen R. de Boer, Esméé Joosten, Fabrizia Fusetti, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Marcel A.T.M. van Vugt. Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B19.

2014

Harmen R. de Boer, Lorenzo Lafranchi, Christine Neugebauer, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Alessandro A. Sartori, Marcel A.T.M. van Vugt. CtIP is regulated by the APC/C-Cdh1 to mediate cell cycle-dependent control of DNA repair. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1315. doi:10.1158/1538-7445.AM2014-1315.

2013

Verweij, Niek, Wouter G. Wieringa, Irene Mateo Leach, Dirk J. van Veldhuisen, Wiek H. van Gilst, Hans L. Hillege, Rudolf S. Fehrmann et al. “GWA Meta-Analysis on ST-T Wave Changes Identifies 12 Novel Loci for Human Cardiac Repolarization.” Circulation 128, no. Suppl 22 (2013): A11627-A11627.2

2012

Altena, Renske, Rudolf SN Fehrmann, Hink Boer, Elisabeth GE de Vries, Coby Meijer, and Jourik A. Gietema. “Macrophage inhibitory cytokine 1 plasma levels in testicular cancer patients during cisplatin combination treatment and their relation to endothelial damage.” In ASCO Annual Meeting Proceedings, vol. 30, no. 15_suppl, p. e15035. 2012.

2011

Marcel A. van Vugt, Rudolf S.N. Fehrmann and Shao-En Ong. A combined bioinformatics and proteomics approach identifies DNA repair factors regulated by the APC/C. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2960. doi:10.1158/1538-7445.AM2011-2960.

2010

Karen van der Weide, Susan D.P.W.M. de Jonge-Peeters, Gerwin A. Huls, Rudolf S.N. Fehrmann, Jan J. Schuringa, Folkert Kuipers, Elisabeth G.E. de Vries and Edo Vellenga. In Vivo Treatment of AML Patients with High-Dose Simvastatin Inhibits Geranylgeranylation In AML Cells. Blood 2010 116:3280. Abstract nr 3280.

Pauline de Graeff, Bea Wisman, Rudolf SN Fehrmann, Anne PG Crijns, Gert Jan Meersma, Haukeline H. Volders, Iris Blijdorp, Marian JE Mourits, Harry Hollema, Steven de Jong and Ate GJ van der Zee. Discovery of novel methylation-based biomarkers for epithelial ovarian cancer using oligonucleotide microarrays. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 161.

2009

Dianne Heijink, Rudolf Fehrmann, Elisabeth de Vries, Dorenda Oosterhuis, Jan Koornstra, Ate van der Zee, Jan Kleibeuker and Steven de Jong. Identification and targeting of biological pathways enriched in colorectal adenomas. In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2872.

Rudolf Fehrmann, Pauline de Graeff, Anne Crijns, Gert Jan Meersma, Harry Klip, Harry Hollema, Gerard te Meerman, Elisabeth de Vries, Ate van der Zee and Steven de Jong. An integrated bioinformatics and functional approach to identify genes and pathways related to platinum resistance in ovarian cancer. In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3878.

2008

Mirjam Boelens, Anke van den Berg, Rudolf Fehrmann, Marie Geerlings, Wouter de Jong, Gerard te Meerman, Hannie Sietsma, Wim Timens, Dirkje Postma and Harry Groen. Smoke-induced and COPD-related epithelial gene expression profiles: relationship with lung cancer. In: Proc Am Assoc Cancer Res; 2008 Apr 12-16; San Diego. Calefornia (CA): AACR; 2008. Abstract nr 1730.

2007

Mirjam Boelens, Anke van den Berg, Gerard te Meerman, Rudolf Fehrmann, Wouter de Jong, Marie Geerlings, Wim Timens, Dirkje Postma and Harry Groen. Lung cancer and COPD: Overlapping origins of disease? In: Proc Am Assoc Cancer Res; 2007 Apr 14-18; Los Angeles. Calefornia (CA): AACR; 2007. Abstract nr 2974.

Mirjam Boelens, Anke van den Berg, Gerard te Meerman, Rudolf Fehrmann, Wouter de Jong, Marie Geerlings, Wim Timens, Dirkje Postma and Harry Groen. Unraveling lymphatic and hematological metastatic behavior of primary squamous cell lung cancer. In: Proc Am Assoc Cancer Res; 2007 Apr 14-18; Los Angeles. Calefornia (CA): AACR; 2007. Abstract nr 4695.