Abstracts

Cyrillo G. Brahm, Annemiek M.E. Walenkamp, Myra E. van Linde, U. Kulsoom Abdul, Bart A. Westerman, Henk M.W. Verheul, Rudolf S.N. Fehrmann. Data-driven prioritization and evaluation of novel therapeutic targets in glioblastoma. 13th Meeting of the European Association of Neuro-Oncology (EANO 2018): 2018 Oct 10-14.

S.H. Hanemaaijer, I.C. Kok, R.S.N. Fehrmann, B. van der Vegt, J.A. Gietema, B.E.C. Plaat, M.A.T.M. Vugt, M.R. Vergeer, J. Voortman, C.R. Leemans, J. Buter, J.A. Langendijk, S.F. Oosting. Comparison of carboplatin with 5-fluorouracil (carbo-5FU) versus cisplatin as concomitant chemoradiotherapy (CRT) for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx374.026.

K.L. Moek, D.J. de Groot, E.G.E. de Vries, R.S.N. Fehrmann. Functional genomic mRNA (FGmRNA) profiling of > 18,000 tumor samples identifies potential new indications for antibody-drug conjugates (ADCs) in a broad range of tumor types. Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx390.070.

R.D. Bense, E.G.E. de Vries, C.P. Schröder, R.S.N. Fehrmann. Higher expression of estrogen response genes in the primary tumor is associated with a greater risk for late recurrence in patients with ER+/HER2-breast cancer. Annals of Oncology, Volume 28, Issue suppl_5, 1 September 2017, mdx362.046.

Cyrillo Gerardo Brahm, Anna Maria Elisabeth Walenkamp, Myra Ellen Van Linde, Henk M.W. Verheul, Rudolf Stephan Nicolaas Fehrmann. Identification of novel therapeutic targets in glioblastoma with functional genomic mRNA profiling. J Clin Oncol 35, 2017 (suppl; abstr 2018).

J.J. Caumanns, G.B.A Wisman, K. Berns, T. Tomar, R.S.N. Fehrmann, R. Bernards, A.G.J. Van der Zee, S. De Jong. Integrative kinome exome sequencing and copy number profiling of ovarian clear cell carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1219 / 4.

Menno Tamminga, T. Jeroen N. Hiltermann, Ed Schuuring, Rudolf S. N. Fehrmann, Harry J. M. Groen. Effect of smoking on tumor-infiltrating immune cell composition and prognosis in non-small cell lung cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 4569 / 14.

Menno Tamminga, T. Jeroen Hiltermann, Ed Schuuring, Rudolf S. N. Fehrmann, Harry J. M. Groen. Prognostic effect of tumor-infiltrating immune cell composition in non-small cell lung cancer by histology. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 2946 / 17.

Stephanie E. van Gijn, Elles Wierenga, Anne Margriet Heijink, Rudolf S. N. Fehrmann, Marcel A. van Vugt. Analysis of 16,172 patient-derived tumor samples indicate TPX2 as being essential for survival of genomically instable cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1409 / 8.

Sergi Guerrero, Rudolf Fehrmann, Marcel ATM van Vugt. Towards an RNA expression-based signature for oncogene-induced replication stress. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract nr 1406 / 5.

Pascal K. C. Jonker, Gooitzen M. van Dam, MD, Sjoukje F. Oosting, Schelto Kruijff and Rudolf S. N. Fehrmann. The identification of novel biomarkers for diagnostic and therapeutic goals in Anaplastic Thyroid Carcinoma using Functional Genomic mRNA Profiling. American Association of Endocrine Surgeons (AAES) Annual Meeting 2016 April 10-12; Baltimore (MD), USA.

E Hartmans, V Orian-Rousseau, A Matzke-Ogi, A Karrenbeld, D J A de Groot, S de Jong, G M van Dam, R S N Fehrmann, W B Nagengast. CD44 and its splice variant CD44v6 as Potential Imaging and Treatment Targets for Colorectal Adenomas. 6th Dutch Experimental Gastroenterology and Hepatology (DEGH) meeting: 2016 Mar 16-18; Veldhoven, The Netherlands.

Bense RD, van der Vegt B, de Vries EGE, van Vugt MATM, Schröder CP, Fehrmann RSN. Inverse relationships between high somatic copy number load and immune phenotypes in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-08-01.

Harmen R. de Boer, Esméé Joosten, Fabrizia Fusetti, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Marcel A.T.M. van Vugt. Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B19.

Harmen R. de Boer, Lorenzo Lafranchi, Christine Neugebauer, Rudolf S.N. Fehrmann, Elisabeth G.E. de Vries, Alessandro A. Sartori, Marcel A.T.M. van Vugt. CtIP is regulated by the APC/C-Cdh1 to mediate cell cycle-dependent control of DNA repair. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1315. doi:10.1158/1538-7445.AM2014-1315.

Verweij, Niek, Wouter G. Wieringa, Irene Mateo Leach, Dirk J. van Veldhuisen, Wiek H. van Gilst, Hans L. Hillege, Rudolf S. Fehrmann et al. “GWA Meta-Analysis on ST-T Wave Changes Identifies 12 Novel Loci for Human Cardiac Repolarization.” Circulation 128, no. Suppl 22 (2013): A11627-A11627.

Altena, Renske, Rudolf SN Fehrmann, Hink Boer, Elisabeth GE de Vries, Coby Meijer, and Jourik A. Gietema. “Macrophage inhibitory cytokine 1 plasma levels in testicular cancer patients during cisplatin combination treatment and their relation to endothelial damage.” In ASCO Annual Meeting Proceedings, vol. 30, no. 15_suppl, p. e15035. 2012.

Marcel A. van Vugt, Rudolf S.N. Fehrmann and Shao-En Ong. A combined bioinformatics and proteomics approach identifies DNA repair factors regulated by the APC/C. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2960. doi:10.1158/1538-7445.AM2011-2960.

Karen van der Weide, Susan D.P.W.M. de Jonge-Peeters, Gerwin A. Huls, Rudolf S.N. Fehrmann, Jan J. Schuringa, Folkert Kuipers, Elisabeth G.E. de Vries and Edo Vellenga. In Vivo Treatment of AML Patients with High-Dose Simvastatin Inhibits Geranylgeranylation In AML Cells. Blood 2010 116:3280. Abstract nr 3280.

Pauline de Graeff, Bea Wisman, Rudolf SN Fehrmann, Anne PG Crijns, Gert Jan Meersma, Haukeline H. Volders, Iris Blijdorp, Marian JE Mourits, Harry Hollema, Steven de Jong and Ate GJ van der Zee. Discovery of novel methylation-based biomarkers for epithelial ovarian cancer using oligonucleotide microarrays. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 161.

Dianne Heijink, Rudolf Fehrmann, Elisabeth de Vries, Dorenda Oosterhuis, Jan Koornstra, Ate van der Zee, Jan Kleibeuker and Steven de Jong. Identification and targeting of biological pathways enriched in colorectal adenomas. In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2872.

Rudolf Fehrmann, Pauline de Graeff, Anne Crijns, Gert Jan Meersma, Harry Klip, Harry Hollema, Gerard te Meerman, Elisabeth de Vries, Ate van der Zee and Steven de Jong. An integrated bioinformatics and functional approach to identify genes and pathways related to platinum resistance in ovarian cancer. In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3878.

Mirjam Boelens, Anke van den Berg, Rudolf Fehrmann, Marie Geerlings, Wouter de Jong, Gerard te Meerman, Hannie Sietsma, Wim Timens, Dirkje Postma and Harry Groen. Smoke-induced and COPD-related epithelial gene expression profiles: relationship with lung cancer. In: Proc Am Assoc Cancer Res; 2008 Apr 12-16; San Diego. Calefornia (CA): AACR; 2008. Abstract nr 1730.

Mirjam Boelens, Anke van den Berg, Gerard te Meerman, Rudolf Fehrmann, Wouter de Jong, Marie Geerlings, Wim Timens, Dirkje Postma and Harry Groen. Lung cancer and COPD: Overlapping origins of disease? In: Proc Am Assoc Cancer Res; 2007 Apr 14-18; Los Angeles. Calefornia (CA): AACR; 2007. Abstract nr 2974.

Mirjam Boelens, Anke van den Berg, Gerard te Meerman, Rudolf Fehrmann, Wouter de Jong, Marie Geerlings, Wim Timens, Dirkje Postma and Harry Groen. Unraveling lymphatic and hematological metastatic behavior of primary squamous cell lung cancer. In: Proc Am Assoc Cancer Res; 2007 Apr 14-18; Los Angeles. Calefornia (CA): AACR; 2007. Abstract nr 4695.