Curriculum Vitae

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Personal details
surname:Fehrmann
First names:Rudolf Stephan Nicolaas
Date of birth:18th April, 1979
Email:rudolffehrmann@gmail.com / r.s.n.fehrmann@umcg.nl

Current positions
2016 - present:Staff member (medical oncologist) at the Department of Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands.
2016 - present:Selected member of the Young Academy of Groningen (YAG). The YAG is a diverse group of early career research scientists from a wide range of disciplines at the University of Groningen. In addition to excellence in research, members have a passion for contributing to issues related to science, policy, diversity, interdisciplinarity and science and society.
2014 - present:Principal investigator at the Cancer Research Center Groningen, University Medical Center Groningen, Groningen, The Netherlands. Participant in the research programmes: 'Guided Treatment in Optimal Selected Cancer Patients (GUTS)' and 'Damage and Repair in Cancer Development and Cancer (DARE)'.
2013 - present:Member of the Ubbo Emmius Fonds (UEF) - Junior Scientific Master class (JSM) Talent Grant Committee, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands.

Education
2014 - 2016:Residency training in Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands.
2012 - 2014:Residency training in Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
2010 - 2012:Residency training in Internal Medicine, Scheper Hospital, Emmen, The Netherlands.
2006 - 2010:MD/PhD joint program, Junior Scientific Masterclass, University Medical Center Groningen, Groningen, The Netherlands, MD degree January 29th 2010 and PhD degree February 3th 2010.
2002 - 2006:MSc degree in Medicine, August 31th 2006, Faculty of Medical Science, University of Groningen, Groningen, The Netherlands.
1998 - 2002:MSc degree in Cognitive Science and Engineering (Artificial Intelligence), August 26th 2002, Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands.
1997 - 1998:Propaedeutic examination in Computer Science, February 29th 2002, Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands.
1991 - 1997:Pre-university education (VWO), Courses: geography, chemistry, mathematics A and B, physics, Dutch, English Ubbo Emmius, Stadskanaal, The Netherlands.

Research experience
2016:Basic course on Regulations and Organisation for clinical investigators (BROK), University Medical Center Groningen, Groningen, The Netherlands.
2014 - present:Principal investigator at the Cancer Research Center Groningen, University Medical Center Groningen, Groningen, The Netherlands. Participant in the research programmes: 'Guided Treatment in Optimal Selected Cancer Patients (GUTS)' and 'Damage and Repair in Cancer Development and Cancer (DARE)'.
2015:Participant in The 17th ECCO-AACR-EORTC-ESMO Workshop on Methods in Clinical Cancer Research, Flims, Switzerland (20 until 26 June 2015).
2010 - 2013:In parallel to my training in Internal Medicine/Medical Oncology: Affiliated as post-doctoral fellow, Departments of Genetics and Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands.
2013:Visiting scientist (Jun-Sep); Subject: Personalized medicine, Supervisor: Prof. Scott Weiss, Partners Healthcare Center for Personalized Genetic Medicine, Harvard Medical School, Boston, MA, USA.
2006 - 2010:PhD research, Supervisors: Prof. A.G.J. van der Zee, Prof. E.G.E. de Vries, Dr. Ir. G.J. te Meerman, Dr. S. de Jong, Title: High dimensional data analysis for new insight in ovarian cancer phenotypes, Departments of Gynecologic Oncology, Medical Oncology and Genetics, University Medical Center Groningen, Groningen, The Netherlands.
2009:Visiting scientist (Sep–Dec); Subject: Translational Oncology, Supervisors: Prof. Stan B. Kaye and Prof. Robert Brown, Institute of Cancer Research and Drug Development Unit, The Royal Marsden Hospital, London, United Kingdom.
2006:Visiting scientist (3 weeks), supported by a personal grant of the Dutch Cancer Society, Subject: Statistical analysis of microarray expression data, Supervisor: Dr. Ricard Simon, Biometric Research Branch, National Cancer Institute (NCI), Bethesda, MD, USA.
2006:MSc thesis, Title: Analysis of ovarian cancer microarray data, Supervisor: Dr. Ir. G.J. te Meerman, Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
2002 - 2006:Bio-informatician (8 hours/week), Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
2002 :MSc thesis, Title: Cognitive navigation modeling of robots, Supervisor: Prof. L. Schomaker, Cognitive Science and Engineering (Artificial Intelligence), Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands.

Teaching experience
2014 - present:Lecturer in Biology of Cancer; Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands .
2016:Lecturer in genetics course Medical Pharmaceutical Drug Innovation (MPDI) topmaster, University Medical Center Groningen, Groningen, The Netherlands.
2014:Lecturer in system biology; Medical Sciences Summer School Oncology 2014; University Medical Center Groningen, Groningen, The Netherlands (July 4th 2014).
2013:Lecturer in integrative genomics; Educational session for residents Gastroenterology and Hepatology; University Medical Center Groningen, Groningen, The Netherlands (December 19th 2013).
2002 - 2005:Teaching assistant in statistics (6 weeks annually), Institute for Medical Education, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands.

Selected lectures and presentations
2017:Harnessing transcriptomic tumour profiles from the public domain; Oral presentation at the East-West Alliance Symposium on big data in health, University of Oxford, United Kingdom (September 12th).
2017:Identification of novel therapeutic targets in glioblastoma with functional genomic mRNA profiling; Poster Discussion Session (presented by C.G. Brahm) at the 2017 ASCO Annual Meeting, Chicago, IL, USA (June 5th).
2017:Tumor profiling (breast cancer immunoinfiltrations); Oral presentation at the 11th training targeted therapy of the Dutch Society of Medical Oncology (NVMO), Driebergen, The Netherlands (March 31th).
2017:Target finding and role of imaging agents in drug discovery; Plenary oral presentation at the International symposium on Molecular Imaging Agents in Medicine 2017, Groningen, The Netherlands (February 13th).
2016:Immune cell type fractions and gene expression in inflammatory breast cancer; Poster and oral presentation (presented by C.P. Schröder) at the 5th International Inflammatory Breast Cancer Conference, Boston, MA, USA (July 10th).
2016:The Identification of novel biomarkers for therapeutic and diagnostic goals in anaplastic thyroid carcinoma using functional genomic mRNA profiling; Oral presentation (presented by Jonker) at AAES 37th Annual Meeting, Baltimore, MD, USA (April 10-12).
2015:Inverse relationships between high somatic copy number load and immune phenotypes in breast cancer; Poster presentation at 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, USA (December 8-12).
2015:In silico immune analysis in breast cancer; Jules Bordet Cancer Institute, Brussels, Belgium (October 5th).
2015:'Van expressieanalyse naar kankertherapie' (Expression analysis to cancer therapy). Oral presentation in honor of retirement of dr. ir. G.J. te Meerman, Groningen, the Netherlands (September 25th).
2014:Multidisciplinaire (inter)nationale benadering op-maat van de kankerpatiënt verbetert behandelresultaten. Avond van Wetenschap & Maatschappij, The Hague, the Netherlands (October 6th).
2013:Functional Genomic mRNA profiling; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA (August 8th).
2013:‘Voor een dubbeltje op de eerste rang’ (For a dime at ring side); J.W.R. Nortier lecture at the NABON-BOOG symposium, Utrecht, the Netherlands (April 11th).
2011:Integrative genomics approach in oncology: towards personalized medicine; Oral presentation at the Oncologiedagen voor Nederland en Vlaanderen, Arnhem, the Netherlands (November 18th).
2011:Towards personalized medicine in oncology: an integrative genomics approach to identify molecular subtypes and to guide treatment choice; Jules Bordet Cancer Institute, Brussels, Belgium (October 31th).
2011:On the brink of control and total chaotic collapse: Analysis of gene expression of 55,000 human samples reveals the cytogenetic architecture of human cancer; Oral presentation at the Second Symposium of Systems Genetics: from man to microbe, from genotype to phenotype, University Medical Center Groningen, Groningen, The Netherlands (September 29th).
2009:Novel approach to identify genes and pathways related to platinum resistance in ovarian cancers; E-Poster Presentation at the 16th International Meeting (ESGO 16), European Society for Gynecological Oncology, Belgrade, Serbia (October 11th).
2009:An integrated bio-informatics and functional approach to identify genes and pathways related to platinum resistance in ovarian cancer; Oral presentation at the 100th Annual Meeting, American Association for Cancer Research, Colorado Convention Center, Denver, CO, USA (April 22th).

Scholarships, grants and prizes
2017:POINTING: Towards patient-tailored cancer immunotherapy supported
by a multifaceted predictive signature composed of integrative omics and
molecular imaging. Dutch Cancer Society (€ 1,988,916). Co-principal investigator.
2016:The Young Leader's Fellowship Grant, European CanCer Organisation (ECCO), European Cancer Congress 2017, Amsterdam, The Netherlands.
2016:Towards a hub for personalized medicine. Institutional funding University Medical Center of Groningen (€478,000). Co-principal investigator.
2016:Towards use of gut microbiome analysis to predict tumor response of patient on immune checkpoint inhibitors: initiating a cohort of patients with advanced solid tumors as a critical first step. UMCG Cancer Research Fund (€42,000). Co-applicant.
2015:Mining big data to improve biologically personalized therapeutics for cancer patients. Veni Grant, NWO/ZonMW (Netherlands Organization for Scientific Research, €250,000 + €40,000). Principal investigator.
2015:Selected as participant in The 17th ECCO-AACR-EORTC-ESMO Workshop on Methods in Clinical Cancer Research, an educational programme that introduces junior clinical oncologists in any oncology subspecialty to the principles of good clinical trial design, Switzerland (20 until 26 June 2015).
2015:Rosenstein award 2014 for the publication Fehrmann et al. “Gene expression analysis identifies global gene dosage sensitivity in cancer” in Nature Genetics. This prize is awarded to a medical specialist in training (Internal Medicine) in the region North and East Netherlands with the best research publication in the last year.
2013:The next step towards improved outcome for patients with genomically unstable tumors (NEXT-GEAR). Bas Mulder Award, personal grant of the Alpe d’HuZes/Dutch Cancer Society (€ 817,000). Principal investigator.
2013:The J.W.R. Nortier lecture. Dutch Breast Cancer Trialists’ Group. This lecture is awarded to a young and talented researcher to present their research to a large audience with scientific interest in breast cancer and its treatment at the annual NABON-BOOG symposium.
2012:Mandema-stipendium, University Medical Center Groningen. The UMCG awards yearly 1 or 2 ‘Mandema- stipendia’ (€ 65,000) to enable young physician-scientists (MD/PhD) to combine their medical specialist training with research and to establish their own line of research.
2011:Pieter de Mulder award, Dutch Association for Medical Oncology (€ 6,000). The objective of this award is to allow a young and talented researcher in the field of oncology to spend a period at a renowned institution abroad for the purpose of promoting his research. This grant partially financed my visit to the Partners Healthcare Center for Personalized Genetic Medicine, Harvard Medical School , Boston, MA, USA.
2006 - 2010
:MD/PhD scholarship, Junior Scientific Master class, University Medical Center Groningen. This program offers students the opportunity to combine their Master phase with a PhD-training to obtain a MD and PhD degree upon completion. In this program students spend an additional two years on scientific research next to the regular medical education.
2006
:Travel grant Dutch Cancer Society to visit Dr. Richard. Simon; Biometric Research Branch, National Cancer Institute (NCI), Bethesda, Maryland, USA

Committees
2016 - present:Selected member of the Young Academy of Groningen (YAG). The YAG is a diverse group of early career research scientists from a wide range of disciplines at the University of Groningen. In addition to excellence in research, members have a passion for contributing to issues related to science, policy, diversity, interdisciplinarity and science and society.
2013 - present:Selected member of the Ubbo Emmius Fonds (UEF) - Junior Scientific Master class (JSM) Talent Grant Committee, Faculty of Medical Sciences, University of Groningen.

People
PhD-students guidance
2017 - present:Carlos G. Urzua, PhD-student, project: POINTING, towards patient-tailored cancer immunotherapy supported by a multifaceted predictive signature composed of integrative omics and molecular imaging.
2016 - present:Arkajyoti Bhattacharya, PhD-student, project: Mining big data to improve biologically personalized therapeutics for cancer patients.
2016 - present:Pascal K.C. Jonker, PhD-student, project: The identification and validation of new biomarkers in thyroid carcinoma and melanoma.
2016 - present:Rico D. Bense, PhD-student, project: Identifying therapeutic targets and modulators of therapy efficacy in breast cancer subgroups.
2016 - present:Xiaojuan Zhao, PhD-student, project: Esophageal cancer.
2015 - present:Thijs T. Wind, PhD-student, project: Imaging and therapeutic targets in melanoma.
2015 - present:Saskia Hanemaaijer, PhD-student, project: New treatment options in head and neck cancer.
2015 - present:Sergi Guerrero, PhD-student, project: Replication stress in tumors.
2014 - present:Stephanie van Gijn, supervision PhD, project: The next step towards improved outcome for patients with genomically unstable tumors (NEXT-GEAR). Bas Mulder Award, Alpe d’HuZes/Dutch Cancer Society.
2014 - 2017:Elmira Hartmans, PhD-research; Supervisors: J.H. Kleibeuker, G.M. van Dam, R.S.N. Fehrmann, W.B. Nagengast; Title of thesis: A new frontier in the field of gastroenterology: Fluorescence Molecular Endoscopy.
Technicians
2015 - present:Elles Wierenga, lab technician.
Research clerkships guidance
2017 :Jorrit Bakker, MSc-thesis; Supervisors: B. Plank, R.S.N. Fehrmann; Title: Predicting the primary origin of Cancer of Unknown Primary using mRNA expression profiles and machine learning.
2016 :Carlos G. Urzua Traslavina, MSc-thesis; Supervisor: R.S.N. Fehrmann; Title: Transcriptional profiles of cancers with unkown primary tumor. (continued as PhD-student)
2015 :Rico D. Bense, MSc-thesis; Supervisors: C.P. Schröder, R.S.N. Fehrmann; Title: Target-finding in Triple-Negative Breast Cancer based on Genomic Instability: a Meta-Analysis. (continued as PhD-student)
2014:Christiaan Serbanescu-Kele, MSc-thesis; Supervisors: B.E.C. Plaat, S.F. Oosting, R.S.N. Fehrmann; Title: Genomic instability is a prognostic maker in head and neck cancer.
Research guidance
2015 - 2016:Pascal K.C. Jonker, MD, project: The identification and validation of new biomarkers in thyroid carcinoma.

Professional memberships
2016 - present:Member of the European Society for Medical Oncology (ESMO).
2016 - present:Full member of the American Society of Clinical Oncology (ASCO).
2016 - present:Active member of the American Association for Cancer Research (AACR).
2014 - present:Member of the Dutch Society of Medical Oncology (NVMO).
2010 - present:Member of the Dutch Society of Internal Medicine (NIV).