Functional Genomic mRNA Profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types

Oncotarget. 2015 Jul 1. [Epub ahead of print] Laetitia E. Lamberts, Derk Jan A. de Groot, Rico D. Bense, Elisabeth G.E. de Vries, Rudolf S.N. Fehrmann The membrane bound glycoprotein mesothelin (MSLN) is a highly specific tumor marker, which is currently exploited as target for drugs. There are only limited data available on MSLN expression…

Big data mining yields novel insights on cancer

Peng Jiang & X Shirley Liu discuss our recent paper in Nature Genetics. Nat Genet. 2015 Jan 28;47(2):103-4. doi: 10.1038/ng.3205. Recent years have seen the rapid growth of large-scale biological data, but the effective mining and modeling of ‘big data’ for new biological discoveries remains a significant challenge. A new study reanalyzes expression profiles from…

Rosenstein award

I’ve been awarded the Rosenstein award 2014 for the publication “Gene expression analysis identifies global gene dosage sensitivity in cancer” that I published in Nature Genetics two week ago. This prize is awarded to a medical specialist in training (Internal Medicine) in the region North and East Netherlands with the best research publication in the…

Biological interpretation of genome-wide association studies using predicted gene functions.

Nat Commun. 2015 Jan 19;6:5890. doi: 10.1038/ncomms6890. Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke M11, Raychaudhuri S1, Fehrmann RS, Hirschhorn JN, Franke L. The main challenge for gaining biological insights…

Growth Differentiation Factor 15 (GDF-15) Plasma Levels Increase during Bleomycin- and Cisplatin-Based Treatment of Testicular Cancer Patients and Relate to Endothelial Damage.

PLoS One. 2015 Jan 15;10(1):e0115372. doi: 10.1371/journal.pone.0115372 Altena R, Fehrmann RS, Boer H, de Vries EG, Meijer C, Gietema JA. INTRODUCTION: Chemotherapy-related endothelial damage contributes to the early development of cardiovascular morbidity in testicular cancer patients. We aimed to identify relevant mechanisms of and search for candidate biomarkers for this endothelial damage. METHODS: Human micro-vascular…