Link to paper Kuipers H, de Bitter TJJ, de Boer MT, van der Post RS, Nijkamp MW, de Reuver PR, Fehrmann RSN,Hoogwater FJH. Simple SummaryKnowledge of genetic alterations in gallbladder cancer (GBC) continues to increase. This systematic review provides an overview of frequently occurring genetic alterations in GBC and describes their possible therapeutic implications. We…
Link to paper Leeuwenburgh VC, Urzúa-Traslaviña CG, Bhattacharya A, Walvoort MTC, Jalving M, de Jong S, Fehrmann RSN. Abstract Background: Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern of all heterogeneous tumor and non-tumor cells present in…
I participated on the program Kunstmatige intelligentie in de zorg (Artificial Intelligence in health care) broadcasted by MedTalk. The interview is in Dutch and you need a Dutch BIG registration to watch the program. The use of artificial intelligence in healthcare is attracting enormous interest. Is it just hype or can we really do something…
Link to paper Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast. Abstract Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive…
The 3th of June Cyrillo Brahm succesfully defended his thesis titled: “Improving the standard of care in glioblastoma: novel diagnostic and therapeutic approaches”. It was a privilege to supervise Cyrillo. I’m also very happy that he started his training for Internal Medicine, and the fact that he may become a colleague medical oncologist in the…
Sergi Guerrero successfully defended his PhD-thesis today! Jointly supervised as co-promotor with Marcel van Vugt. https://www.rug.nl/about-ug/latest-news/events/promoties/?hfId=118982 https://research.rug.nl/nl/publications/exploiting-genomic-instability-as-an-achilles-heel-in-cancer Genomic instability is a hallmark of cancer for which an important cause is the DNA damage generated by oncogene-induced replication stress (RS). Genomically instable cancers increasingly depend on checkpoint kinases, including ATR and WEE1, to activate the DNA…
Link to paper Urzúa-Traslaviña CG, Leeuwenburgh VC, Bhattacharya A, Loipfinger S, van Vugt MATM, de Vries EGE, Fehrmann RSN. ABSTRACT The interpretation of high throughput sequencing data is limited by our incomplete functional understanding of coding and non-coding transcripts. Reliably predicting the function of such transcripts can overcome this limitation. Here we report the use…
Link to paper Astrid A. M. van der Veldt, Sjoukje F. Oosting, Anne-Marie C. Dingemans, Rudolf S. N. Fehrmann, Corine Geurts van Kessel, Mathilde Jalving, Guus F. Rimmelzwaan, Pia Kvistborg, Christian U. Blank, Egbert F. Smit, Valery E. E. P. Lemmens, T. Jeroen N. Hiltermann, Marion P. G. Koopmans, Anke L. W. Huckriede, Nynke Y.…
Link to paper van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K. BackgroundAnastomotic leakage in patients undergoing colorectal surgery is associated with morbidity and mortality. Although multiple risk factors have been identified, the underlying mechanisms are mainly unknown. The aim of this study was to perform a transcriptome…
Very proud that the Dutch Cancer Society is willing to fund the FORCE initiative grant: Infrastructure fOr rare Cancers in the NEtherlands: Towards a comprehensive platform for early detection and treatment of rare cancers: FORCE. FORCE aims to improve treatment outcomes of rare cancers by collecting clinical data on patients with rare cancers and by…